Lam, King Hong

English

The study reported in this thesis was undertaken to obtain more insight in the role of various factors determining the outcome of the interaction between biodegradable polymers and the host in which they are implanted. In the end, the outcome of this interaction determines the success or failure of the implant. Up till now, bioresorbable polymers, such as poly(L-lactide) and poly(g1ycolide) are mostly applied in suture material. However, much research is conducted for other clinical applications. E.g. artificial skin, meniscus prosthesis, abdominal wall prosthesis, nerve guides, bone plates for repairing fractures, small calibre vascular prosthesis, parodontal filters and drug delivery systems. There are many reasons for choosing a bioresorbable material. However, most of them can ultimately be derived from the adage of causing minimal damage to the host. Thus, no foreign material must be left in the host when a biomaterial has performed its function. This goes for drug delivery systems, as well as for those applications in which the function(s) of an organ or tissue is temporarily replaced by a biomaterial or a device made from biomaterials. Only a few of the vast array of polymers applied nowadays are bioresorbable and thus biodegradable

Dissertations of the University of Groningen

   University of GroningenBiocompatibility of degradable biomaterialsLam, King HongIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:1992Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Lam, K. H. (1992). Biocompatibility of degradable biomaterials: a study on the factors determining theinflammatory response against degradable polymers. s.n.CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 11-10-2022

Biocompatibility of degradable biomaterials:a study on the factors determining the inflammatory response against degradable polymers

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Biocompatibility of degradable biomaterials:a study on the factors determining the inflammatory response against degradable polymers

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