Vaccination is a major tool to protect people from seasonal infections of different
strains of influenza virus that presently infects millions of individuals worldwide. Virus genome is
highly polymorphic, and universal vaccine that protects against permanently changing virus is still
under development. Despite notable differences between humans and rodents in the disease course,
immunobiology and clinical evaluations, murine infectious models remain one of the major tools to test
approaches for influenza vaccine development
