During the last fifty years remarkable results are achieved in the application of nuclear technology for the production of electricity. Looking ahead to the next fifty years it is clear that the demand for energy will grow considerably and also the requirements for the way the energy will be supplied. Within the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO), the future of the energy demand and supply was explored and several scenario's identified. A leading requirement for energy supply is coming up and will play a crucial role: sustainability of the way the energy supply will be realized. Fulfilling the growing need for energy in developing countries is as well an important issue. Based on these scenario's for the next fifty years, an inventory of requirements for the future of nuclear energy systems has been collected as well a methodology developed by INPRO to assess innovative nuclear systems and fuel cycles. On the base of this assessment, the need for innovations and breakthroughs in existing technology can be defined. To facilitate the deployment of innovative nuclear systems also the infrastructure, technical as well as institutional has to be adjusted to the anticipated changes in the world such as the globalization. As a contribution to the conference the main messages of INPRO will be presented
