Climate change is one of the most significant global challenges faced by today's society and the environment. Climate change has implications for the nature, social life, and also the area of cultural heritage. Climate change and the vulnerability becomes a hazard to other conservation areas. We must prepare for the worst alternative of climate change in order to protect the cultural heritage sites of damage. Currently, the area of cultural heritage preservation in Semarang have many problems, such as flooding problems, rob, and unhealthy living conditions. Many historic buildings were damaged condition and rob and drowned because of flooding. So, we need to know what area mapping and how the impacts of climate change on the region, and then solve the problem. While this issue is resolved, we can maintain the characteristics of the heritage area, and will enhance the character of the whole city as well as help provide a good image for Semarang.Based on the above , this study aims to: 1 ) analyze the phenomenon of climate change in Kampung Melayu Semarang; 2 ) Identify the characteristics of vulnerability in Malay Kampung Semarang, 3 ) Investigate the impact of climate change on the vulnerability of the region, and then 4 ) Formulate form of resistance region to climate change is happening.This study tries to combine quantitative and qualitative methods. And approaches used to support research activities are spatial approach. Based on the results of the above study it can be concluded that the shape of the climate resilience of the historical district in Kampung Melayu Semarang form of adaptation the transformation of the building and no action. Thus the future of Semarang recommended to the Government to be able to cope with the flood problem of local historic buildings that were there can still be maintained and Kampung Melayu can last from existing climate change