Fibrosis Hati

Abstract

Liver fibrosis is the excessive accumulation of an extracellular matrix proteins that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in cirrhosis, liver failure, and often requires liver transplantation. The knowledge of the cellular and molecular mechanisms of liver fibrosis has greatly advanced   This paper describes some  molecular events that occur following hepatic stellate cell activation and its role in fibrogenesis. Reversibility of advanced liver fibrosis in patients has been recently documented, which has stimulated researchers to develop antifibrotic drugs. Emerging antifibrotic therapies are aimed at inhibiting the accumulation of  fibrogenic cells and/or preventing the deposition of  extracellular matrix proteins. Although many therapeutic interventions are effective in experimental models of liver fibrosis, their efficacy and safety in humans are unknown. This review summarizes recent progress in the study of the pathogenesis and diagnosis of liver fibrosis and discusses current antifibrotic strategies