This study aims to determine the effect of guided inquiry learning for students' scientific literacy skills. The research was conducted at SMAN 24 Kabupaten Tangerang along January-June 2013. The method used was quasi-experimental, research subjects in this study were 77 students, divided into 2 groups: the experimental group and the control group. Research design in this study was the nonequivalent control group design. The instrument used was the science literacy test and observation sheet used. The research shows that students' science literacy for experimental group (mean = 54.49 and standard deviation = 18.67) was lower than the control group (mean = 57.63 and standard deviation of 14.37). After Mann-Whitney test (at the 95% significance level) α values obtained for 0.293 > 0.05. It can be concluded there is no significant difference between the average science literacy experimental group and control group students