Kadar Apolipoprotein B dan Aterosklerosis Arteri Karotis Interna pada Pasien Pasca Stroke Iskemik

Abstract

Relations between apolipoprotein B level with internal carotid artery atherosclerosis in post ischemic stroke patientBackground: Ischemic stroke is caused by brain artery obstruction or brain artery narrowing called atherosclerosis. Its marker is the thickness of tunica intima-media (intima-media thickness/IMT) of the artery. Apolipoprotein B is one of the indicator of atherosclerosis diseases. Most of the previous studies investigate association between apolipoprotein B level and cardiovascular disease, while the association between apolipoprotein B and atherosclerosis in post ischemic stroke patients has not been studied yet.Objective: To investigate association between apolipoprotein B level and internal carotid artery atherosclerosis based on thickness of intima-media in patients post ischemic stroke.Method: This cross-sectional study was done in post ischemic stroke (first attack) subjects in outpatient clinic of Neurology Department Kariadi Hospital Semarang, during December until February 2011. Apolipoprotein B level was measured with Integra method, during 1 month after the onset. The thickness of tunica intima-media of the internal carotid artery was measured by Ultrasonography Duplex.Result: Fourty four patients post ischemic stroke that met the inclusion and exclusion criteria, comprise of 22 male (50%) and 22 female (50%). Atherosclerosis which was defined as tunica intima-media thickness >0.9 mm, was found in 24 subjects (54.6%). Apolipoprotein B level, which designated as high if apoB >105 mg/dl, was found in 25 subjects (56.8%). Multivariate logistics regression test controlling lipid factor as confounding factors resulted in OR 142.1 (p=0.0001).Conclusion: Apolipoprotein B level significantly correlate with atherosclerosis of internal carotid artery represented by thickness of intima-media in patients post ischemic stroke