Hubungan Malaria Dengan Tnf-α Dan Kadar Hemoglobin Pada Ibu Hamil Di Kabupaten Bolaang Mongondow Utara

Abstract

: As an infectious transmitted disease, malaria has been a tremendous health problem around the world. Indonesia is determined as one of the 104 malaria-endemic countries in the world. Pregnant women are easier infected by malaria compared with the general population. People suffered from malaria may have low haemoglobin and high TNF-α levels. The increased TNF α level may cause bad complication or mortality in malaria patient. This study aimed to determine the levels of hemoglobin and TNF-α among pregnant woman with malaria in Kabupaten Bolaang Mongondow Utara. This was a cross-sectional study. Samples were obtained by using purposive sampling method. Besides using questionnaire, there were three laboratory tests conducted in this study: peripheral blood smear with Giemsa staining for detection of plasmodia; hemoglobin level with rapid test hemoglobin; and TNF-α level with ELISA. The bivariate analysis showed that of 72 pregnant women there was only one (1.4%) with positive malaria and increased TNF-α level. There was no pregnant woman with malaria had low hemoglobin level. The chi square test showed a P value 1,00 (α = 0,05). Conclusion: There was no relation between plasmodium infection and the levels of TNF α and hemoglobin among pregnant women in Kabupaten Bolaang Mongondow Utara