Dabbagh, A.

Eippert, F.

Gross-Wege, N.

Horn, U.

Kaptan, M.

Möller, H.

Trampel, R.

Vannesjo, J.

Weiskopf, N.

English

MPG.PuRe

Why spinal cord? Challenges of spinal cord fMRIPain signals arise from the nociceptors and aretransmitted via the spinal cord to the brain.Pain is an important warning signal, but theperception of pain does not always exhibit a one-to-one relationship with tissue damage. Instead theperception of pain can be modulated by manydifferent factors.BOLD responses in 7T fMRI of the human spinal cord on a single-subject levelUlrike Horn1, Nicolas Gross-Wege1,2, Johanna Vannesjo3, Merve Kaptan1, Alice Dabbagh1, Robert Trampel1, Harald Möller1, Nikolaus Weiskopf1,4, Falk Eippert11Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Siemens Healthcare GmbH, Erlangen, Germany, 3Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway, 4Felix Block Institute for Solid State Physics, University of Leipzig, Leipzig, Germanyuhorn@cbs.mpg.deResults1SummaryOHBM, 20222PainExpectationPrior experienceAttentiono Very small cross-section o Partial volume effectso Low signal-to-noise-ratioHigher field strength (7T)o Only a few custom-built coils existo Field inhomogeneities present a significant problemo Impact of physiological noise Methodsbut:123456789101112131415161718192021222324Custom-built spinal cord coil(24 channels, MRI.TOOLS)Susceptibility-matched pads around the neck for passive shimmingSkin conductanceRespirationPulseHeat pain stimulation4 runs with 8 pain trials eachPain onPain off30sEPI, 0.75mm in-plane, 3 mm slice thickness, TR 1.12s, TE 23ms,GRAPPA acceleration factor 3C6SetupImagingLeft dorsalExemplary slice stackTarget regionPreprocessing• Slice-wise motion correction (SCT)• Motion-correction parameters included in GLM• Automated censoring of outlier volumes• Multi-step non-linear warping to template spaceStatistical analysis• FSL FEAT• Slice-wise physiological noise modelling (PNM)• Cardiac noise• Respiratory noise• CSF fluctuationssagittalaxialsagittalaxialData quality differs across participants …Cord segmentations based on anatomicalscans overlaid on functional scans showwhere distortions and signal drop-outs occur.… but is reproducible.One way how these factors can influence painperception is via descending pathways that influenceearlier stages of the processing hierarchy. ………………This means the very first modulation of nociceptivesignals can already take place in the spinal cord. Butdespite its importance and potential clinicalrelevance, our knowledge of the human spinal cord inlight of pain perception is still limited.• fMRI of the human spinal cord at 7T faces many technical challenges• Single-subject spinal cord BOLD responses to painful heat stimulation in expected region, but consistency of responses across participants currently unclear• Next step: evaluating distortion correction of EPI data to allow more fine-grained response delineation in grey matter• Ultimate goal: sufficient data quality to investigate interplay of bottom-up and top-down factors in pain perception in different layers of dorsal horn5 We observe BOLD responses to painful heat…Z = 3.75Z = 3.85Z = 2.20 Z = 2.53Z = 4.23In 5 out of our 9 participants we observe activation in theexpected location, suggesting that task-based functionalMRI in spinal cord is indeed feasible at 7T.InhalationExhalationWe select participants based on criteria…4 … that ensure good data quality.dorsal ventralventralMRI-based screening procedureN = 46Pain experimentN = 9 7 male, 2 female,age mean 31.6 yA!"#$A%#%&6 … and accompanying autonomous responses.3Session 1 Session 2Therefore:Funding sourcesStG: GA ID: 758974See also poster WTH1010@ulrike_horn

BOLD responses in 7T fMRI of the human spinal cord on a single-subject level

http://hdl.handle.net/21.11116/0000-000B-1DA8-8

BOLD responses in 7T fMRI of the human spinal cord on a single-subject level

Abstract

Similar works

Full text

Available Versions

MPG.PuRe