Background: Hypothyroidism during pregnancy has an adverse effect on both mother and child. Children born untreated have profound effect on future intellectual development and mothers do have complications during pregnancy and delivery. Method: 92 (ninety two) pregnant women aged between 20 to 35 years having hypothyroidism were studied. BMI, CBC, Lipid-profile, BUN, serum creatinine, TSH free T4 and anti TPO antibodies test was carried out by using Roch modular kit using ECLIA technology. Results: BMI, GA, Cholesterol, BUN, Sr creatinine, ESR, Granulocytes and Hb% parameters had quite abnormal profile. Thyroid profile of first trimester had 6.8 (±1.3) TSH, 0.4 (±0.1) F T4, 13.2 (±0.5) Anti TpoAb. Conclusion: This pragmatic study of hypothyroidism in First trimester of pregnancy will be a tool for physician or endocrinologist to treat such patients efficiently to avoid the risk factors to both maternal and foetus as well
