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Radiomics-guided deep neural networks stratify lung adenocarcinoma prognosis from CT scans
Authors
Eunjin Kim
Hwan-ho Cho
+5 more
Hyunjin Park
Junmo Kwon
Jonghoon Kim
Geewon Lee
Ho Yun Lee
Publication date
1 November 2021
Publisher
'Springer Science and Business Media LLC'
Doi
Cite
Abstract
© 2021, The Author(s).Deep learning (DL) is a breakthrough technology for medical imaging with high sample size requirements and interpretability issues. Using a pretrained DL model through a radiomics-guided approach, we propose a methodology for stratifying the prognosis of lung adenocarcinomas based on pretreatment CT. Our approach allows us to apply DL with smaller sample size requirements and enhanced interpretability. Baseline radiomics and DL models for the prognosis of lung adenocarcinomas were developed and tested using local (n = 617) cohort. The DL models were further tested in an external validation (n = 70) cohort. The local cohort was divided into training and test cohorts. A radiomics risk score (RRS) was developed using Cox-LASSO. Three pretrained DL networks derived from natural images were used to extract the DL features. The features were further guided using radiomics by retaining those DL features whose correlations with the radiomics features were high and Bonferroni-corrected p-values were low. The retained DL features were subject to a Cox-LASSO when constructing DL risk scores (DRS). The risk groups stratified by the RRS and DRS showed a significant difference in training, testing, and validation cohorts. The DL features were interpreted using existing radiomics features, and the texture features explained the DL features well.11Nsciescopu
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oai:pr.ibs.re.kr:8788114/10867
Last time updated on 24/12/2021
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Last time updated on 14/02/2022