CT-DNA interaction, Fluorescence binding and Microbial activity of Schiff base metal complexes derived from 4-bromobenzaldehyde and 2-amino-6-methylbenzothiazole

Abstract

A novel bidentate Schiff base ligand was prepared by the condensation of 4-bromobenzaldehyde and 2-amino-6-methylbenzothiazole. The ligand has been characterized by microanalytical data such as IR, UV-Vis, 1H-NMR, EPR and Mass spectra. Its complexes of Cu (II), Ni (II), Co (II), and Zn (II) were synthesized and characterized by spectral and analytical techniques. This fact shows the composition of the type ML2 where, M= Cu (II), Ni (II), Co (II), and Zn (II). The UVV is spectral data implies that the complexes have octahedral geometry. They show non electrical conductance which reveals that these chelates are electrolytes. Their magnetic susceptibility values afford evidence for the monomeric nature. Absorption and gel electrophorese experiments have been accepted out on the interaction of the complexes with CT-DNA and results suggest that all the complexes of DNA and Fluorescence binding. The Antimicrobial activities of the compounds are tested in vitro against four bacteria