Experiential avoidance (EA) is a process in which a person attempts to avoid, dismiss, or change experiences such as emotions, behaviors, and thoughts. EA is associated with a number of psychological disorders and is generally harmful to psychological well-being. Various studies have explored the role of EA as a mediator, while others have studied EA as a moderator. The current study aimed to further understand and broaden the knowledge of the role of EA in regard to trauma, substance abuse, aggression, and impulsivity by examining relationships between these variables with EA as a mediator and as a moderator. Experientially avoidant behaviors (i.e., substance abuse, aggression, and impulsivity) were related to higher levels of EA. EA was found to partially mediate the relationship between the number of traumatic experiences and posttraumatic stress disorder (PTSD) symptoms, as well as the relationship between substance abuse and PTSD. EA was also found to moderate the relationship between PTSD symptoms and aggression. Findings from the present study as well as its limitations and future directions for research are discussed