Biomolecular ineractions of platinum complexes

Abstract

The in vitro and in vivo effects of platinum complexes have been well reported. However, it is their interactions with biologically relevant structures and bio-macromolecules such as DNA and proteins that can determine their therapeutic effects. The pharmacological properties of platinum complexes are dependent on binding interactions, and the investigation of such interactions is essential to gain insight into the mechanisms of action. Interactions with DNA can inhibit cellular processes such as replication and transcription, which are vital for the proliferation of cells. By investigating how platinum complexes achieved these different interactions we may be able to determine the relationships between the structural characteristics, biophysical properties and biological activity in order to design more effective anticancer drugs