In this study, methanol extracts from the leaf and stem of Dolichandrone spathacea (L.f) K.
Schum., a lesser-known local mangrove tree species, was evaluated using disc diffusion and minimum inhibitory
concentration (MIC) value determination assays against six strains of local MRSA clinical isolates
and one ATCC MRSA reference strain. The stem extract exhibited a higher zone of inhibition as compared
with the leaf extract against the tested isolates. Further qualitative evaluation of the stem extract
showed MIC values between 1.25 to 1.88 mg/ml against three selected MRSA clinical isolates. Phytochemical
screening revealed that the triterpene and saponin compounds might be responsible for the better inhibitory
activity from the stem extract as compared to the leaf extract. This study is the first report of the
phytochemical screening and the inhibitory activity of D. spathacea leaves and stems methanolic extracts
against MRSA clinical isolates.Colegio de Farmacéuticos de la Provincia de Buenos Aire
