Cardiac hypertrophy is the most potent cardiovascular risk factor after age, with relative mortality risk greater in women. The cognate issue of whether ischaemia coincident with hypertrophic co-morbidity has differing gender aetiology/outcome has not been addressed. We used a novel polygenic model of hypertrophy to examine male/female cellular stress responses in normal and hypertrophic cardiomyocytes.Centro de Investigaciones Cardiovasculare