Mesalam, Ahmed Atef Ahmed Abouzeid

Ghent University Academic Bibliography

Ahmed A. Mesalam  Center for Vaccinology Ghent University A broadly neutralizing monoclonal antibody targeting  HCV prevents viral infection in vitro and in human liver chimeric mice Introduction  Hepatitis C virus: positive stranded RNA virus   enveloped particle: E1 and E2   7 genotypes   DAA therapies: improved SVR   HCV induced end stage liver disease:   poor therapy efficacy    liver transplantation   universal infection of liver graf   Neutralizing antibodies ?  HCVpp  1a  2a In vitro characterization of anti-HCV mAb-2A5 HCVcc Day -3 mAb Bleeding weekly Virus Day 0  1b   4a  6a   1a  In vivo characterization of anti-HCV mAb-2A5 Conclusion:  mAb-2A5 neutralizes HCV in vitro and in vivo. mAb-2A5 could be used to prevent HCV infection of liver graft. Acknowledgements University of Nottingham Richard Urbanowicz Jonathan Ball Karolinska University Daniel Johansson Mats Persson Ghent University  Isabelle Desombere Lieven Verhoye Freya Van Houtte Ali Farhoudi Karin Weening Koen Vercauteren Geert Leroux-Roels Philip Meuleman Funding: Reagents:  Charles M. Rice  Jens Bukh  Thomas F. Baumert  Arvind Patel    Jane A. McKeating Stanford University Zhen-Yong Keck Steven Foung  

A broadly neutralizing monoclonal antibody targeting HCV prevents viral infection in vitro and in human liver chimeric mice

https://biblio.ugent.be/publication/8530854/file/8530855

A broadly neutralizing monoclonal antibody targeting HCV prevents viral infection in vitro and in human liver chimeric mice

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Ghent University Academic Bibliography