Background: The aim of this research was to determine which of two chosen questionnaires for subjective symptoms of dry eye
(Ocular Surface Disease Index and Schein questionnaire) is more reliable in the assessment of dry eye in patients with
schizophrenia.
Subjects and methods: Our research included 80 patients (160 eyes) of both sexes with schizophrenia ranging between the age of
25 and 55 who have been taking one of three antipsychotic drugs namely clozapin, olanzapin, quetiapin for five or more years and
were in a stable phase of the disease or remission. All participants were required to satisfy all included and excluded criteria. They
all filled out the Schein and OSDI questionnaires for assessment of subjective symptoms. Tear break-up time test (TBUT) for
objective evaluation of tear film stability was also performed. In order to determine the correlation between two subjective and
objective tests we calculated Spearmans correlation coefficients.
Results: Obtained results of the correlation between OSDI questionnaire and TBUT test for the right eye was r=-0.73; p<0.01
and for the left eye was r=-0.72; p<0.01. Results of the correlation between Schein questionnaire and TBUT test for the right eye
was r=-0.62; p<0.01 and for the left eye was r=-0.60; p<0.01. A detailed analysis shows that there are no statistically significant
differences between the correlations. Both subjective questionnaires are statistically significantly and negatively related to the TBUT
test, showing that an increase in the results on the OSDI and Schein\u27s questionnaires led to the decreases in the results on the TBUT test.
Conclusion: In patients with schizophrenia the OSDI and Schein questionnaires are equally reliable in the assessment of
subjective symptoms of Dry eye disease. Considering that, OSDI is more common in clinical practice and includes questions
regarding quality of life, it would have certain advantages and it is recommended for use in patients with schizophrenia
