A member of the Vincentian Family, the nonprofit Depaul International serves people who are homeless throughout Europe and the US, a mission which became much more difficult during the COVID-19 pandemic. After giving some of the organization’s history, J. Patrick Murphy describes the challenges that staff and service users faced and how both groups (and donors) responded in extraordinary ways. He offers specific stories from different countries that illustrate how “staff shared common Vincentian values, provided leadership, increased communication, and shared resources and best practices across boundaries.” Depaul International members were asked what Vincent de Paul would say of their work, and their reflections are presented in their original words