Baczkó István

Farkas András

Farkas Attila S.

Füzesi Tamás

Jdid Saddik M.

Pintér Jenő A.

Polyák Alexandra

Varró András

English

University of Szeged

 112  8th European Section Meeting of the International Academy of Cardiovascular Sciences (IACS); September 28 – October 1, 2022; Szeged, Hungary AORTIC PRESSURE POSITIVELY AFFECTS LEFT VENTRICULAR PRESSURE IN ISOLATED, LANGENDORFF-PERFUSED GUINEA PIG AND RAT HEARTS  Jenő A. Pintér1, Saddik M. Jdid1, Alexandra Polyák1, Tamás Füzesi1, András Varró2,3, István Baczkó2, Attila S. Farkas1, András Farkas1  1Department of Internal Medicine, Cardiology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary  2Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary  3Working Group of Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, Hungary  The Langendorff-perfused isolated heart is a commonly used cardiovascular experimental model. Previously, we proved that, contrary to popular belief, the left ventricle is loaded and ejects in this model, similarly to physiological conditions. However, it is unclear how aortic (column) pressure affects left ventricular pressure and ejection. We recorded the left ventricular pressure, aortic pressure and aortic flow in Langendorff-perfused, isolated guinea pig (n=33) and rat (n=29) hearts. The hearts were randomly assigned into one of three predetermined aortic pressure groups: 60, 70, or 80 mmHg. Elevating aortic pressure increased left ventricular pressures (max. left ventricular pressure in guinea pig hearts [mean±SE]: 71.0±1.4 mmHg, 87.8±1.1 mmHg, 97.9±1.5 mmHg in 60, 70, and 80 mmHg group, respectively, p<0.05; max. left ventricular pressure in rat hearts: 71.8±2.1 mmHg, 79.0±2.7 mmHg, 91.7±3.5 mmHg in 60, 70, and 80 mmHg group, respectively, p<0.05). In guinea pig hearts, elevating aortic pressure increased stroke volume and cardiac output (stroke volume: 6.6±2.1 µl, 21.0±4.6 µl, 29.4±8.1 µl in 60, 70, and 80 mmHg group, respectively, p<0.05; cardiac output: 1.39±0.44 ml/min, 4.04±0.79 ml/min, 6.19±1.53 ml/min in 60, 70, and 80 mmHg group, respectively, p<0.05). On the contrary, aortic pressure did not affect stroke volume or cardiac output in rat hearts. In Langendorff-perfused guinea pig and rat hearts, aortic pressure positively affects left ventricular pressure. In guinea pig hearts, elevating aortic pressure increases stroke volume and cardiac output, whereas aortic pressure does not affect these parameters in rat hearts indicating an interspecies difference.  Keywords: Langendorff-perfused hearts, aortic pressure, left ventricular pressure, stroke volume, cardiac output.                  

Aortic pressure positively affects left ventricular pressure in isolated, langendorff-perfused guinea pig and rat hearts : [abstract]

http://acta.bibl.u-szeged.hu/77572/1/iacs_es_2022_112.pdf

Aortic pressure positively affects left ventricular pressure in isolated, langendorff-perfused guinea pig and rat hearts : [abstract]

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