Csont Tamás

Csupor Dezső

Demján Virág

Fejes Alexandra

Földesi Imre

Gausz Flóra Diána

Kiss Tivadar

Pipicz Márton

Siska Andrea

Szűcs Gergő

Sója Andrea

English

University of Szeged

72 8th European Section Meeting of the International Academy of Cardiovascular Sciences (IACS); September 28 – October 1, 2022; Szeged, Hungary STELLARIA MEDIA TEA MAY IMPROVE CARDIAC DYSFUNCTION IN DIABETIC RATS WITHOUT AFFECTING THE GLUCOSE HOMEOSTASIS Virág Demján1,2,3, Andrea Sója1,2,3, Tivadar Kiss2,4, Alexandra Fejes1,2,3, Flóra Diána Gausz1,2,3, Gergő Szűcs1,2,3, Andrea Siska5, Imre Földesi5, Dezső Csupor2,4,6, Márton Pipicz1,2,3 and Tamás Csont1,2,31University of Szeged, Faculty of Medicine, Department of Biochemistry, Metabolic Diseases and Cell Signaling Group (MEDICS), Szeged, Hungary 2University of Szeged, Interdisciplinary Centre for Natural Products, Szeged, Hungary 3University of Szeged, Interdisciplinary Centre of Excellence, Szeged, Hungary 4University of Szeged, Faculty of Pharmacy, Department of Pharmacognosy, Szeged, Hungary 5University of Szeged, Faculty of Medicine, Department of Laboratory Medicine, Szeged, Hungary 6University of Pécs, Faculty of Medicine, Institute for Translational Medicine, Pécs, Hungary Although in folk medicine common chickweed (Stellaria media) tea has traditionally been applied for treating diabetes, evidence is still missing. We aimed to assess the effect of Stellaria media tea on glucose homeostasis and cardiac function in a diabetic rat model. Diabetes was induced by fructose-enriched diet and a single injection of low dose streptozotocin. Half of the animals received hot water extract of Stellaria media tea (100 mg/kg) by oral gavage. At the end of the 20-week experimental period, blood samples were collected and isolated working heart perfusions were conducted. Increased fasting serum glucose level, diminished glucose tolerance and decreased cardiac output were in diabetic rats. Stellaria media tea did not affect fasting hyperglycemia or glucose intolerance; nevertheless, it attenuated diabetes-induced deterioration of cardiac performance. In association, cardiac STAT3 phosphorylation induced by diabetes was prevented by Stellaria media extract.  We demonstrated for the first time that Stellaria media tea may improve diabetic cardiac dysfunction without affecting glucose homeostasis. STAT3 signaling may be implicated in the protection of Stellaria media tea against diabetic cardiomyopathy. Keywords: cardiovascular prevention, medicinal herb, diabetic co-morbidity, cardioprotection Funding: GINOP-2.3.2-15-2016-00012, GINOP-2.3.2-15-2016-00006, EFOP-3.6.2-16-2017-00006, K115990, K115796 and PD128271, 20391–3/2018/FEKUSTRAT, UNKP-19-3-SZTE-47, UNKP-20-2–SZTE-60, UNKP-20-2–SZTE-61 

Stellaria media tea may improve cardiac dysfunction in diabetic rats without affecting the glucose homeostasis : [abstract]

http://acta.bibl.u-szeged.hu/77533/1/iacs_es_2022_072.pdf

Stellaria media tea may improve cardiac dysfunction in diabetic rats without affecting the glucose homeostasis : [abstract]

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University of Szeged