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A multivariate twin study of hippocampal volume, self-esteem and well-being in middle-aged men
Authors
AM Dale
LT Eyler
+18 more
C Fennema-Notestine
B Fischl
CE Franz
MD Grant
RL Hauger
DH Hellhammer
AJ Jak
TL Jernigan
WS Kremen
TS Kubarych
SJ Lupien
MJ Lyons
SP Mendoza
MC Neale
MS Panizzon
EC Prom-Wormley
LJ Seidman
MT Tsuang
Publication date
7 May 2012
Publisher
eScholarship, University of California
Abstract
Self-esteem and well-being are important for successful aging, and some evidence suggests that self-esteem and well-being are associated with hippocampal volume, cognition and stress responsivity. Whereas most of this evidence is based on studies on older adults, we investigated self-esteem, well-being and hippocampal volume in 474 male middle-aged twins. Self-esteem was significantly positively correlated with hippocampal volume (0.09, P = 0.03 for left hippocampus, 0.10, P = 0.04 for right). Correlations for well-being were not significant (Ps > 0.05). There were strong phenotypic correlations between self-esteem and well-being (0.72, P < 0.001) and between left and right hippocampal volume (0.72, P < 0.001). In multivariate genetic analyses, a two-factor additive genetic and unique environmental (AE) model with well-being and self-esteem on one factor and left and right hippocampal volumes on the other factor fits the data better than Cholesky, independent pathway or common pathway models. The correlation between the two genetic factors was 0.12 (P = 0.03); the correlation between the environmental factors was 0.09 (P > 0.05). Our results indicate that largely different genetic and environmental factors underlie self-esteem and well-being on one hand and hippocampal volume on the other. © 2012 The Authors. Genes, Brain and Behavior © 2012 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society
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Last time updated on 25/12/2021