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How to apply the movement disorder society criteria for diagnosis of progressive supranuclear palsy.
Authors
Angelo Antonini
Thomas Arzberger
+36 more
Kailash P Bhatia
Adam Boxer
Carlo Colosimo
Yaroslau Compta
Jean-Christophe Corvol
Leslie Ferguson
Ellen Gelpi
Armin Giese
Lawrence I Golbe
Max-Joseph Grimm
Murray Grossman
Günter U Höglinger
David J Irwin
Keith A Josephs
Jan Kassubek
Anthony E Lang
Johannes Levin
Irene Litvan
Wassilios G Meissner
Huw R Morris
Movement Disorder Society-endorsed PSP Study Group
Christer Nilsson
Wolfgang H Oertel
Alexander Pantelyat
Ines Piot
Werner Poewe
Alex Rajput
Gesine Respondek
Sigrun Roeber
James B Rowe
Maria Stamelou
Claire Troakes
Thilo van Eimeren
John C van Swieten
Gregor K Wenning
Jennifer L Whitwell
Publication date
1 August 2019
Publisher
eScholarship, University of California
Abstract
BackgroundThe Movement Disorder Society criteria for progressive supranuclear palsy define diagnostic allocations, stratified by certainty levels and clinical predominance types. We aimed to study the frequency of ambiguous multiple allocations and to develop rules to eliminate them.MethodsWe retrospectively collected standardized clinical data by chart review in a multicenter cohort of autopsy-confirmed patients with progressive supranuclear palsy, to classify them by diagnostic certainty level and predominance type and to identify multiple allocations.ResultsComprehensive data were available from 195 patients. More than one diagnostic allocation occurred in 157 patients (80.5%). On average, 5.4 allocations were possible per patient. We developed four rules for Multiple Allocations eXtinction (MAX). They reduced the number of patients with multiple allocations to 22 (11.3%), and the allocations per patient to 1.1.ConclusionsThe proposed MAX rules help to standardize the application of the Movement Disorder Society criteria for progressive supranuclear palsy. © 2019 International Parkinson and Movement Disorder Society
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Last time updated on 25/12/2021