Behning, C.

Binns, A. M.

Crabb, D. P.

Dunbar, H. M. P.

Finger, R. P.

Higgins, B. E.

Holz, F. G.

Leal, S.

Luhmann, U. F. O.

Sassmannshausen, M.

Schmid, M.

Schmitz-Valckenberg, S.

Terheyden, J. H.

Thiele, S.

Tufail, A.

Zakaria, N.

City Research Online

              City, University of London Institutional RepositoryCitation: Dunbar, H. M. P., Sassmannshausen, M., Behning, C., Thiele, S., Binns, A. M., Higgins, B. E., Terheyden, J. H., Tufail, A., Leal, S., Zakaria, N., et al (2022). Comparison of visual function in structurally defined sub-phenotypes of intermediate AMD: A MACUSTAR study report. Investigative Ophthalmology & Visual Science, 63(7), ISSN 0146-0404 This is the published version of the paper. This version of the publication may differ from the final published version. Permanent repository link:  https://openaccess.city.ac.uk/id/eprint/29361/Link to published version: Copyright: City Research Online aims to make research outputs of City, University of London available to a wider audience. Copyright and Moral Rights remain with the author(s) and/or copyright holders. URLs from City Research Online may be freely distributed and linked to.Reuse: Copies of full items can be used for personal research or study, educational, or not-for-profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. City Research OnlineCity Research Online:            http://openaccess.city.ac.uk/            publications@city.ac.uk1/2Comparison of visual function in structurally definedsub-phenotypes of intermediate AMD: A MACUSTARstudy report | IOVSiovs.arvojournals.org/article.aspxOpen AccessARVO Annual Meeting Abstract  |   June 2022Comparison of visual function in structurally defined sub-phenotypes of intermediateAMD: A MACUSTAR study reportAuthor Affiliations & NotesInvestigative Ophthalmology & Visual Science June 2022, Vol.63, 880. doi:AbstractPurpose : To investigate whether reclassifying eyes with intermediate (i)AMD byadditional imaging-based biomarkers identifies sub-phenotypes of iAMD with reducedvisual function (VF).Methods : People with no AMD and Beckman defined iAMD in the MACUSTAR studyperformed Best Corrected Visual Acuity (BCVA), Low Luminance Visual Acuity (LLVA),Moorfields Acuity Test (MAT), Pelli Robson Contrast Sensitivity (CS), InternationalReading Speed Test (IReST), Mesopic (MesAT) and Scotopic (ScoAT) average thresholds(S-MAIA microperimetry) and AdaptDx Rod Intercept Time (RIT), followed bymultimodal imaging (colour fundus and confocal infrared photography, fundusautofluorescence and spectral domain optical coherence tomography). Images weregraded by a central reading centre for presence of the following features: pigmentaryabnormalities (PA), reticular pseudodrusen (RPD), incomplete and complete retinalpigment epithelium and outer retinal atrophy (iRORA and cRORA). Pairwise complete VFdata were compared across three structurally defined groups; no AMD, iAMD featureabsent(-) and iAMD feature present(+) using nonparametric Kruskal-Wallis, followed bypairwise Wilcoxon tests. Being a signal seeking exploratory analysis, multiple testingcorrection was not applied.Results : 224 people (n=56 no AMD [33F; mean age 68 yrs]; n=168 iAMD [106F; 71 yrs])were included in this analysis. Of those with iAMD, 96(57%) had PA, 37(22%) had RPD,18(11%) had iRORA and 7(4%) had cRORA. With the exception of IReST, those withiAMD and absent structural features had worse median VF than those with no AMD on allmeasures (p<0.01). LLVA, CS, MesAT, ScoAT and RIT were worse in those withiAMD+RPD compared to iAMD–RPD (p<0.04). LLVA, CS, MAT, MesAT and ScoAT wereworse in those with iAMD+cRORA compared to iAMD–cRORA (p<0.05). CS was worsein those with iAMD+PA compared to iAMD–PA (p=0.01). There were no mediandifferences between presence or absence of iRORA in any VF measure.2/2Conclusions : Though ascribed the same AMD disease stage, eyes with iAMD+RPD andiAMD+cRORA had poorer low luminance and contrast vision than other iAMD eyes. Asthe number of eyes with observed structural features is small, we aim to confirm ourfindings in a large longitudinal cohort and examine whether additional structural orfunctional features should be accounted for in AMD disease classification or used as entrycriteria in treatment trials.This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May1-4, 2022, and virtually.This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.Advertisement  

Comparison of visual function in structurally defined sub-phenotypes of intermediate AMD: A MACUSTAR study report

https://openaccess.city.ac.uk/id/eprint/29361/1/iovs.arvojournals.org-Comparison%20of%20visual%20function%20in%20structurally%20defined%20sub-phenotypes%20of%20intermediate%20AMD%20A%20MACUSTAR%20s.pdf

Comparison of visual function in structurally defined sub-phenotypes of intermediate AMD: A MACUSTAR study report

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