Anne, Sauvaget

Caroline, Berjamin

Charles, Laidi

David, Szekely

Dominique, Januel

Emmanuel, Poulet

Filipe, Galvao

Jérôme, Brunelin

Marion, Plaze

Maud, Rotharmel

Noomane, Bouaziz

René, Benadhira

Samuel, Bulteau

English

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ABSTRACTS Psychiatria Danubina, 2022; Vol. 34, Suppl. 3, pp 10-57    S36 BI-FRONTAL tDCS CAN IMPROVE FACIAL EMOTION RECOGNITION IN MAJOR DEPRESSIVE DISORDER: AN EXPLORATORY PILOT STUDY  Laetitia Imbert1,2,3, Rémi Moirand1,2,3, Benoit Bediou4,  Emmanuel Poulet1,2,3 & Jérôme Brunelin1,2,3 1INSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, PSYR2 Team, Lyon, France 2Université Lyon 1, Lyon University, Villeurbanne, France 3Centre Hospitalier Le Vinatier, Bron, France 4Université de Genève, Faculté de psychologie et Sciences de l'Education Campus Biotech, Genève, Suisse The dorsolateral prefrontal cortex (DLPFC) plays a pivotal role in both depressive symptoms and emotional processing. Recently, transcranial Direct Current Stimulation (tDCS) applied over the DLPFC hold promises to alleviate clinical symptoms in patients with MDD. However, only a few studies investigated the effect of tDCS on emotional processing whereas antidepressant drugs are known to improve such deficits in patients with MDD. Here, we investigated the effect of DLPFC-tDCS a facial emotion recognition task (FER) in patients with MDD.  In a randomized sham-controlled study, 40 patients with treatment-resistant MDD received a single session (30 min) of either active (2 mA, n=18) or sham tDCS (n=17). The anode was placed over the left and the cathode over the right DLPFC, respectively. FER was assessed before and after the stimulation session.  After active tDCS, we observed an overall improvement in FER performance as compared with sham tDCS. The beneficial effect seemed mainly drive by an improved recognition of Sad faces. No significant effect of the sham stimulation was observed. The session was well tolerated. Although exploratory, these results suggest that a single session of tDCS may improve social cognition in patients with MDD. Further studies are needed to replicate these results and investigate whether this acute improvement of FER in response to tDCS could translate into clinical benefits as observed with antidepressant drugs.  * * * * *     REAL WORLD TRANSCRANIAL MAGNETIC STIMULATION FOR MAJOR DEPRESSION IN FRANCE: A MULTISITE, NATURALISTIC, RETROSPECTIVE STUDY Bouaziz Noomane1, Laidi Charles2, Bulteau Samuel3, Berjamin Caroline4, Benadhira René1,  Szekely David5, Poulet Emmanuel6,7, Galvao Filipe7, Sauvaget Anne3, Plaze Marion8,9,  Rotharmel Maud4, Brunelin Jérôme6,7 & Januel Dominique1 1EPS Ville Evrard, Pôle 93G03, Centre de Recherche Clinique, Neuilly-sur-Marne, Paris, France 2Pôle de Psychiatrie, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine de Créteil,  DMU IMPACT, Hôpitaux Universitaires Mondor, Créteil, Paris, France 3CHU Nantes, Department of Addictology and Psychiatry, Nantes, France 4University Department of Psychiatry, Centre d'Excellence Thérapeutique - Institut de Psychiatrie-Centre Hospitalier du Rouvray, Sotteville-lès-Rouen, France 5CH Princess Grace, Monaco, Monaco 6Psychiatric emergency service, Hospices civils de Lyon, Lyon, France 7CentreHospitalier Le Vinatier, PSYR2 team, Bron, Lyon, France 8GHU Paris Psychiatrie & Neurosciences, Hôpital Sainte-Anne, Service Hospitalo-Universitaire,  Pôle Hospitalo-Universitaire Paris 15, Paris, France 9Université de Paris, Paris, France Background: Repetitive Transcranial Magnetic Stimulation (TMS) was approved in 2008 by the US FDA. Meta-analyses of randomized controlled trials have confirmed its efficacy in the treatment of depression. However, real-world outcomes of rTMS remain understudied. We aimed to study how TMS therapy used to treat depression is delivered in routine clinical practice in France, and to measure its effectiveness and potential moderators of this effectiveness. ABSTRACTS Psychiatria Danubina, 2022; Vol. 34, Suppl. 3, pp 10-57    S37 Methods: Five French centers provided data on patients treated with TMS for resistant depression between January 2015 and December 2020. We included patients who were assessed by a hetero-questionnaire and had a baseline and immediate posttreatment assessment. We performed univariate analyses to investigate which factors were significantly associated with the efficacy of TMS. Next, we included age, sex, and significant factors in a multivariate model. Results: 435 patients were included; 66% of individuals with depression were female and 26% had bipolar depression. Stimulation was delivered with four different stimulation parameters: 1Hz (7% of individuals), 10Hz (43%), 50Hz (38%), and 20Hz (12%). TMS resulted in a significant decrease in MADRS (Delta=9.47 (8.73, MW Stat. 150319.5, p<0.001) with a large effect size (CLES=0.79). The mean improve-ment was 33% (SD=31%). Response and remission rates were 31% and 23%, respectively. In multivariate analysis, improvement in depressive symptoms was associated with higher baseline symptoms. Conclusion: TMS is effective in routine clinical practice. Response prediction and personalized targeting could improve its effectiveness. * * * * *    BRAIN PERFUSION ALTERATIONS INDUCED BY STANDALONE AND COMBINED TRANSCRANIAL STIMULATION OVER THE PREFRONTAL CORTEX:  A RANDOMIZED, PLACEBO-CONTROLLED STUDY, USING 99mTc SPECT Lais B. Razza1,2,3, Carlos Buchpiguel4, Fábio Duran4, Stefanie De Smet2,3, Chris Baeken2,3,5,  Marie-Anne Vanderhasselt2,3,5 & André R. Brunoni1,4 1Department of Internal Medicine, Faculty of Medicine, University of Sao Paulo,  Laboratory of Neurosciences (LIM-27), São Paulo, Brazil 2Ghent Experimental Psychiatry (GHEP) lab, Ghent, Belgium 3Department of Head and Skin, Ghent University Hospital, Ghent, Belgium 4Instituto Nacional de Biomarcadores em Neuropsiquiatria (INBioN), Department and Institute  of Psychiatry, Faculdade de Medicina, Universit São Paulo, Brazil 5Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium Background: Non-invasive brain stimulation (NIBS) approaches have been increasingly used to target the prefrontal cortex (PFC), with mixed results in the fields of cognitive and behavioral neuroscience. Recent studies suggest that the combination of distinct NIBS techniques may maximize required changes in brain activity. However, it is unclear whether NIBS combinations could also enhance prefrontal cortical activity and its neurocircuitry. To evaluate the application of standalone and combined protocols of transcranial direct current stimulation (tDCS) and intermittent theta-burst stimulation (iTBS) over the left dorsolateral PFC (DLPFC) of healthy volunteers through Single Photon Emission Computed Tomography (SPECT) neuroimaging. Methods: A randomized, double-blind, sham-controlled, full-factorial design was conducted. Partici-pants received four different stimulation protocols (tDCS, iTBS, Combined Interventions and Placebo), one per week, over the DLPFC located by structural neuronavigation. TDCS was applied with a current of 2mA for 20 minutes and iTBS with 1620 pulses for 9 minutes. A radiopharmaceutical (99mTc-ECD) was administered immediately after the start of the iTBS protocol. An adverse effects scale was applied after the end of the neurostimulation session and the SPECT was collected afterwards.  Results: Twenty-five adults with a mean age of 28.6 years (standard deviation (SD) = 7) were included. Of those, 23 underwent 4 sessions while 2 underwent only the first neurostimulation session. The first findings of the neuroimaging data analyses show that the combined intervention significantly modulated deeper regions from the PFC, such as the left anterior (p=0.03) and the right posterior cingulate cortex (p=0.02), while the tDCS protocol increased the blood flow of the orbitofrontal right (p=0.04) and left (p=0.02) cortices in comparison with the placebo protocol. iTBS alone did not show significant results compared to placebo. However, those are preliminary findings and will be further explored to be presented at the conference. Finally, all active protocols were similarly tolerable. * * * * *  

REAL WORLD TRANSCRANIAL MAGNETIC STIMULATION FOR MAJOR DEPRESSION IN FRANCE: A MULTISITE, NATURALISTIC, RETROSPECTIVE STUDY

REAL WORLD TRANSCRANIAL MAGNETIC STIMULATION FOR MAJOR DEPRESSION IN FRANCE: A MULTISITE, NATURALISTIC, RETROSPECTIVE STUDY

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