Acne is an inflammatory disease of the pilo-sebaceous unit,
which mainly affects young adolescents. The pathogenesis is multifactorial,
as a combination of genetic predisposition, hormonal production,
hyper-seborrhea, inflammation and overgrowth of C. acnes. Moreover, dietinduced
hyperinsulinemia can lead to sebocyte stimulation, androgen production,
and thus acne lesions. Pharmacological therapeutic approaches
are varied and include topical and systemic antibiotics and, in severe cases,
systemic retinoids, with several side-effects. However, increasing evidence
has shown that adequate vitamin supplementation, use of probiotics, and
proper nutrition with low carbohydrates and fats intake, can significantly
contribute to the patient’s clinical improvement. In this review, we describe
the role of probiotics, vitamins, alimentation, antioxidants, UV exposure,
and plants in acne disease
