The analysis of 35,087 kidney stones revealed that 60% of uric acid stones originate from the left kidney whereas other stones are homogeneously distributed (p<0.001). The analysis of (i) lateralized urine samples collected during ureteroscopy and (ii) urine from patients grafted with left or right kidney, did not reveal any difference in urine from left and right kidney. Patients affected by uric acid stones had significantly more cysts, predominating in the left kidney, than patients affected by calcium oxalate stones (p<0.001). This set of experiments suggests that renal cysts are associated to uric acid stone lateralization on the left side
