Solvent Proton Magnetic Relaxation in Solution of Rabbit Liver Cytochrome P450. On the Corfelation Time for the Electron Proton Dipole-Dipole Interaction
Structural parameters can be derived from PMR measurements
if the correlation time fdr the spin interactions is known. The relaxation
rates induced by the ferric haem-iron of cyt P450 were
found to be frequency independent from 10 to 37 MHz. The possible
limits for the correlation time according to Solomon\u27s theory are
discussed with regard to the possible existence of a water molecule
at the sixth coordination site of the haem-iron. No definite conclusion
could be reached in this respect, but the results are definetely
in favour of a haem environment which can accomodate several
water molecules exchanging quickly with the bulk of solvent
