Cilj istraživanja bio je analizirati klinička obilježja, laboratorijske
nalaze, liječenje, tijek bolesti i ishod pojedinih oblika
vaskulitisa u djece. U istraživanje su bili uključeni svi bolesnici
u dobi do 18 godine života kojima je u razdoblju od
2002. do 2012. godine u Klinici za pedijatriju KBC-a Zagreb
utvrđena dijagnoza vaskulitisa prema kriterijima EULAR/
PRES/PRINTO. Vaskulitis je dijagnosticiran u 180 djece, 101
djevojčice i 79 dječaka, u dobi 7,19±3,7 godina. Prosječno
vrijeme praćenja bolesnika bilo je 5,58±3,28 godina. Henoch-
Schönleinova purpura (HSP) dijagnosticirana je u 155
bolesnika (86 %), nodozni poliarteritis (PAN) u 6 (3,3 %),
izolirani kutani leukocitoklastični vaskulitis u 5 (2,8 %), Takayasuov
arteritis (TA) u dva (1,1 %), Kawasakijeva bolest
(KB) u dva (1,1 %), hipokomplementarni urtikarijski vaskulitis
u jednog (0,5 %) te drugi vaskulitisi u 10 (5,5 %) bolesnika
(vaskulitisi povezani sa sistemnim bolestima veziva u sedam
i neklasifi cirani u tri bolesnika). U svih bolesnika upalni
laboratorijski parameteri (C-reaktivni protein, sedimentacija eritrocita) bili su povišeni. Antineutrofi lna citoplazmatska
protutijela (ANCA) bila su pozitivna u samo jednog bolesnika
s mikroskopskim poliarteritisom. Potporne mjere liječenja
u obliku nesteroidnih protuupalnih lijekova bili su način
liječenja u većine bolesnika, dok su bolesnici sa zahvaćenim
bubrežnim i gastrointestinalnim sustavom tretirani glukokortikoidima
i/ili imunosupresivima. U bolesnika s najtežim
simptomima primijenjena je i biološka terapija (anti-CD20,
rituksimab). Tijekom praćenja umrlo je jedno dijete (0,56%)
oboljelo od mikroskopskog poliarteritisa radi zatajenja bubrega.
Četrdeset bolesnika (22,6%) je imalo jedan relaps, a
šest (3,4%) dva relapsa bolesti. Zaključno, primijetili smo
neke razlike u naših bolesnika u odnosu na literaturne podatke,
poput niže učestalosti povišenih vrijednosti antistreptolizinskog
O titra u bolesnika s HSP-om te veće učestalosti
PAN-a u ženskog spola, dok se ostala klinička obilježja, laboratorijski
nalazi, liječenje i ishod nisu razlikovali.Th e aim of our study was to analyze clinical features, laboratory
fi ndings, treatment, course and outcome of diff erent
types of vasculitis in children. All children aged up to 18 years
that have been diagnosed with a vasculitis disorder from 2002.
to 2012. at the Department of Paediatric, University Hospital
Centre Zagreb according to EULAR/PRES/PRINTO criteria
were included in the study. Vasculitis was diagnosed in 180
children, 101 girls and 79 boys, mean age 7.19±3.7 years, with
an average follow-up of 5,58±3,28 years. Most of the children
(155 or 86%) were diagnosed with Henoch-Shönlein purpura
(HSP), polyarteritis nodosa (PAN) was diagnosed in 6 children
(3.3%), isolated cutaneous leukocytoclastic vasculitis in
5 (2.8%), Takayasu arteritis (TA) and Kawasaki disease in 2
(1.1%) respectively, hypocomplementemic urticarial vasculitis
in one patient (0.5%) and other types of vasculitis in 10
(5.5%) patients (vasculitides in systemic connective tissue
disorders in 7 and unclassifi ed vasculitides in 3 patients).
All patients had elevated infl ammatory markers (C-reactive protein and erythrocyte sedimentation rate). Anti-neutrophil
cytoplasmatic antibodies (ANCA) were positive only in one
patient, suff ering from microscopic polyangiitis. Treatment
modality in most patients were NSAIDs, while children with
kidney or gastrointestinal system aff ection were treated with
glucocorticoids and/or immunosuppresive drugs. Biological
therapy (anti-CD20, rituximab) was used in patients with
most severe symptoms. One child (0.56%), suff ering from
microscopic polyangiitis, died due to kidney failure during
the follow-up. Forty patients (22.6%) had one disease relapse,
while 6 (3.4%) had two relapses. In conclusion, we found
some diff erences in laboratory parameters (e.g. lower incidence
of elevated antistreptolysin O titer in HSP) and epidemiological
data (e.g. higher prevalence of PAN in female
children) in comparison to data from available studies, while
other clinical features, laboratory fi ndings, disease outcome
and treatment were similar