It has been known for many years that the excessive consumption of sugar (sucrose) has harmful effects on human health. This fact led to a reduction in sugar consumption and the appearance of artificial sweeteners in the 1800s. The first low-cost and low-calorie sugar alternative was saccharin. Since this sweetener gained great popularity, other artificial sweeteners soon followed, including aspartame, acesulfame-K and cyclamates as the most common ones. As the result of a sharp rise in the obesity pandemic in all populations and ethnic groups, a demand for sweeteners with a minimum caloric value has increased dramatically in the last decade as consumers care more about their health. Due to the different regulation of permitted artificial sweeteners in United States (US) and Europe (EU), there are some controversies and suspicions about the relationship between certain sweeteners and a potential health risk. Despite doubts about the safety of artificial sweeteners, many studies have shown the absence of dangers associated with their use (if used in the acceptable daily intake, ADI). Therefore, artificial sweeteners today are considered as safe for consumption by many competent institutions and organisations. Nowadays, artificial sweeteners are fundamental in the food industry and present in many foodstuffs
