De Fazio, Chiara

Di Bernardini, Eugenio

Grejs, Anders M

Jeppesen, Anni Nørgaard

Kirkegaard, Hans

Kjaergaard, Jesper

Laitio, Timo

Rasmussen, Bodil Sten

Skrifvars, Markus B

Storm, Christian

Søreide, Eldar

Taccone, Fabio Silvio

Tianen, Marjaana

English

BACKGROUND: No data are available on the quality of targeted temperature management (TTM) provided to out-of-hospital cardiac arrest (OHCA) patients and its association with outcome.METHODS: Post hoc analysis of the TTH48 study (NCT01689077), which compared the effects of prolonged TTM at 33 °C for 48 h to standard 24-h TTM on neurologic outcome. Admission temperature, speed of cooling, rewarming rates, precision (i.e. temperature variability), overcooling and overshooting as post-cooling fever (i.e. &gt;38.0 °C) were collected. A specific score, ranging from 1 to 9, was computed to define the "quality of TTM".RESULTS: On a total of 352 patients, most had a moderate quality of TTM (n = 217; 62% - score 4-6), while 80 (23%) patients had a low quality of TTM (score 1-3) and only 52 (16%) a high quality of TTM (score 7-9). The proportion of patients with unfavorable neurological outcome (UO; Cerebral Performance Category of 3-5 at 6 months) was similar between the different quality of TTM groups (p = 0.90). Although a shorter time from arrest to target temperature and a lower proportion of time outside the target ranges in the TTM 48-h than in the TTM 24-h group, quality of TTM was similar between groups. Also, the proportion of patients with UO was similar between the different quality of TTM groups when TTM 48-h and TTM 24-h were compared.CONCLUSIONS: In this study, high quality of TTM was provided to a small proportion of patients. However, quality of TTM was not associated with patients' outcome.</p

Quality of targeted temperature management and outcome of out-of-hospital cardiac arrest patients:A post hoc analysis of the TTH48 study

Skrifvars, Markus B.

Grejs, Anders M.

Copenhagen University Research Information System

https://vbn.aau.dk/files/475421245/De_Fazio_et_al._Resuscitation_2021_DRAFT.pdf

Quality of targeted temperature management and outcome of out-of-hospital cardiac arrest patients:A post hoc analysis of the TTH48 study

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