Bigot, G

Bonadonna, RC

Bonnemaire, M

Ciocca, A

Freemantle, N

Gourdy, P

Jamoul, C

Mauricio, D

Mueller-Wieland, D

English

UCL Discovery

actors Associated With Glycemic Control In People With Type 1 Diabetes (PWT1D) Switched To Once Daily (QD) Insulin Glargine (Gla) 300 U/mL (Gla- 300): The European REALI Pooled Database Author Block: DIRK MÜLLER-WIELAND, PIERRE GOURDY, RICCARDO C. BONADONNA, NICK FREEMANTLE, GREGORY BIGOT, CORINNE JAMOUL, ALICE CIOCCA, MIREILLE BONNEMAIRE, DIDAC MAURICIO, Aachen, Germany, Toulouse, France, Parma, Italy, London, United Kingdom, Levallois-Perret, France, Louvain- la-Neuve, Belgium, Paris, France, Barcelona, Spain Abstract: Aim: To study potential factors associated with improved glycemic control in PWT1D switching from QD or twice-daily (BID) basal insulin (BI) to QD Gla-300. Methods: Data from PWT1D in the European REALI pooled database who switched to Gla-300 were analyzed by multivariable ANCOVA to determine factors related to HbA1c change from baseline (BL) to 6 months (6 M) post-treatment. Variables with p<0.10 in the final model were retained. Results: A total of 455 PWT1D (TOUJEO-NEO, N=397; OPTIMIZE, N=58) were pooled, of whom 436 received Gla-300. Mean age was 50.0±14.7 years and median (Q1, Q3) diabetes duration was 18.0 (10.0, 27.0) years. Almost half of PWT1D (47.3%) presented with ≥1 cardiovascular disease/risk factor and 16.7% with diabetes complications. Mean±SD BL HbA1c was 8.3±0.84%; and change from BL to 6 M was -0.43±0.81%. A total of 179/427 (41.9%) PWT1D received BID BI, 39.1% used Gla-100, and overall mean±SD BI dose was 30.4±17.8 U/day. High BL HbA1c (p<0.0001), prior non-insulin glucose-lowering agent (p=0.027), and absence of diabetes complications (p=0.058) were associated with greater reductions in HbA1c, but not prior BID BI regimen (Table). Conclusion: Likelihood of achieving clinically important HbA1c reduction in PWT1D switched to QD Gla-300 was mostly dependent on BL HbA1c, and not on previous BID BI regimen.  

Factors Associated with Glycemic Control in People with Type 1 Diabetes (PWT1D) Switched to Once Daily (QD) Insulin Glargine (Gla) 300 U/mL (Gla-300): The European REALI Pooled Database

https://discovery.ucl.ac.uk/id/eprint/10141988/3/Freemantle_Factors%20Associated%20with%20Glycemic%20Control%20in%20People%20with%20Type%201%20Diabetes%20%28PWT1D%29%20Switched%20to%20Once%20Daily%20%28QD%29%20Insulin%20Glargine%20%28Gla%29%20300%20U%3AmL%20%28Gla-300%29_AAM.pdf

Factors Associated with Glycemic Control in People with Type 1 Diabetes (PWT1D) Switched to Once Daily (QD) Insulin Glargine (Gla) 300 U/mL (Gla-300): The European REALI Pooled Database

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