The hepatocellular carcinoma is more common in African and Asian countries with an incidence in women at around 5.5/10,000. Hepatocellular carcinoma is an aggressive tumour, with high recurrence rates, reaching around 50%. Hepatocellular carcinoma is rare in pregnant women. In the English literature, we have found only one case of hepatocellular carcinoma recurrence during pregnancy that was described in a 39 years old patient with the recurrence occurring during her second pregnancy. In our work, we describe the second case of pregnancy complicated by recurrent, advanced and inoperable hepatocellular carcinoma. We also present a literature review about management challenges and the importance of multi-disciplinary care in pregnant women with hepatocellular carcinoma
