Ageusia is a rare condition characterized by loss of taste functions of the tongue.A large number of conditions may be responsible for causing ageusia. Adverseeffects of drug therapy are the most common cause for the loss of taste. Ageusiacan have a significant effect on the quality of life of patients and can lead to lossof appetite, weight, and may require discontinuation of drug administration inalready compromised patients. We present two cases of ageusia one associated withamitriptyline in a patient with endogenous depression and the other with terbinafinein patient with tinea unguium