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Sex-Specific associations of brain-derived neurotrophic factor and cardiorespiratory fitness in the general population
Authors
Diana Albrecht
Martin Bahls
+18 more
Marcus Dörr
Ina Eiffler
Ralf Ewert
Stephan B. Felix
Nele Friedrich
Sven Gläser
Hans-Jörgen Grabe
Jan C. Gras
Stefan Groß
Deborah Janowitz
Juliane Kopp
Stephanie Könemann
Marcello R.P. Markus
Matthias Nauck
Marie-Lena Schmalhofer
Antje Steveling
Henry Völzke
Kristin Wenzel
Publication date
1 January 2019
Publisher
Basel : MDPI
Doi
Cite
Abstract
The brain-derived neurotrophic factor (BDNF) was initially considered to be neuron-specific. Meanwhile, this neurotrophin is peripherally also secreted by skeletal muscle cells and increases due to exercise. Whether BDNF is related to cardiorespiratory fitness (CRF) is currently unclear. We analyzed the association of serum BDNF levels with CRF in the general population (Study of Health in Pomerania (SHIP-TREND) from Northeast Germany; n = 1607, 51% female; median age 48 years). Sex-stratified linear regression models adjusted for age, height, smoking, body fat, lean mass, physical activity, and depression analyzed the association between BDNF and maximal oxygen consumption (VO2peak), maximal oxygen consumption normalized for body weight (VO2peak/kg), and oxygen consumption at the anaerobic threshold (VO2@AT). In women, 1mL/min higher VO2peak, VO2peak/kg, and VO2@AT were associated with a 2.43 pg/mL (95% confidence interval [CI]: 1.16 to 3.69 pg/mL; p = 0.0002), 150.66 pg/mL (95% CI: 63.42 to 237.90 pg/mL; p = 0.0007), and 2.68 pg/mL (95% CI: 0.5 to 4.8 pg/mL; p = 0.01) higher BDNF serum concentration, respectively. No significant associations were found in men. Further research is needed to understand the sex-specific association between CRF and BDNF. © 2019 by the authors. Licensee MDPI, Basel, Switzerland
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Last time updated on 23/07/2022