Most high school graduates are unemployed and unemployment can be reduced by inviting people to open new businesses or entrepreneurship, especially among teenagers. . This study aims to determine the partial and simultaneous effect of self-efficacy, family social support, and entrepreneurial knowledge on students interest in entrepreneurship. By using a sampling technique that is non-random sampling with a population of 116 students. The analysis method uses multiple linear regression analysis with the help of the SPSS 26 program. . The results of this study indicate that there is a partially positive effect of self-efficacy on students' interest in entrepreneurship, there is no partial positive effect of family social support on students' interest in entrepreneurship and there is no partial positive effect of entrepreneurial knowledge on students' interest in entrepreneurship. And simultaneously self-efficacy, family social support, and entrepreneurial knowledge on students' interest in entrepreneurship have a positive effect with a significant value
