The feelings of guilt by parents of children with limited health and functional disorders are the deep-psychological formation of interpersonal genesis caused by moral suffering as a result of the disability of the child, determined by the intensity of the mechanisms of psychological protection, intrapersonal conflicts; mediated by the personal qualities of the parents. Pathologization of the experience of guilt reveals a relationship with the types of attitude to the disease and the status of the child, has an ambivalent nature and tendency to hypercompensation. It is conceptualized and empirically proven that the sense of guilt of parents of children with disabilities is complex, primary in relation to intrasymeological traumatization by an experience that has a deep psychological determination associated with a specific set of mechanisms of psychological defenses, the presence of appropriate intrapersonal conflicts and irrational attitudes. The features of the experience of interpersonal guilt in terms of their conjunctive and disjunctive effects are analyzed. A set of moral traumatization of parents is defined, which describes the moral suffering from the recognition of a child’s disability and the phenomenon of secondary trauma due to the conviction of guilt before the child (family members, society, etc.). Moral trauma from guilt has two rational attributes: moral harm–moral losses associated with moral and physical suffering, limitations, losses, and moral suffering–negative experiences that manifest themselves in the form of fear, shame, humiliation, a state of mental pain, depression and apathy. Behavioral trends and obsessive thoughts about compensation and