ABSTRACTObjective: This present study is designed to explore the neuroregenerative effects of d-α-tocopherol on peripheral nerve in both healthy and diabeticrats.Methods: 24 albino rats were divided into four groups; healthy control, diabetic control, healthy treated, and diabetic treated. Diabetes was inducedby single subcutaneous injection of alloxan (100 mg/kg). Treated groups were administered d-α-tocopherol orally, daily (200 mg/kg) for 3 weeks.Through a mid-thigh incision, sciatic nerve was crushed with Kocher's forceps, and skin wound was closed with absorbable suture. Sciatic functionaland static indices were used to assess the functional recovery in conjunction with histological, histomorphological, and biochemical analyses at theend of 3 weeks.Results: It was noticed that d-α-tocopherol supplementation accelerates functional recovery, enhances the antioxidant levels, and promotes theregeneration and extracellular matrix reorganization of peripheral nerves.Conclusion: It is concluded that the d-α-tocopherol appears to be an optimistic option in the management of peripheral nerve crush injury in bothhealthy and diabetics.Keywords: Antioxidant, d-α-tocopherol, Diabetes, Rats, Regeneration, Sciatic nerve
