IMPAIRED OBJECT RECOGNITION MEMORY AND ACETYLCHOLINESTERASE ACTIVITY IN ANIMAL MODEL OF POST-TRAUMATIC STRESS DISORDER-RESTORED BY ECLIPTA ALBA LINN. A DIETARY HERB.
ABSTRACTObjective: Acetylcholinesterase (AChE) inhibitors are important therapeutic targets to treat memory impairment caused due to stress, post-traumaticstress disorder (PTSD) results from traumatic stress exposure. Cognition and mood symptoms can begin or worsen after the traumatic event. In thisstudy, we aimed to evaluate the role of Eclipta alba Linn. as an antistressor, AChE inhibitor, and on object recognition memory in an animal model of PTSD.Methods: Adult male Wistar albino rats were randomly divided into four groups: Control, chronic unpredictable stress (CUS) (30 days), CUS+ethanolicextract of E. alba (EEEA) (200 mg/kg body weight), and EEEA (200 mg/kg body weight) treatment groups and were assessed for novel objectrecognition task (NORT), plasma corticosterone, and AChE activity.Results: We found significant improvement in NORT (p<0.05) plasma corticosterone levels in stress group was significantly increased (p<00.05)which is resumed with EEEA treatment (p<0.05) AChE activity was found to be reduced after EEEA treatment.Conclusion: EEEA is found to possess cognitive enhancing activity in the animal model of PTSD.Keywords: Recognition memory,PTSD,Unpredictable stress,Eclipta alb
