ABSTRACTAcne vulgaris is a disease associated with sebaceous follicle. It starts appearing after the onset of puberty and can extend up to 40-50 years of age. Asfar as the pathogenesis of acne is concerned, it is not fully understood up till now. Treatment of acne is very frustrating and involves an understandingof etiopathological factors. This review focuses on various factors accountable, pathogenesis, and therapy of acne.Keywords: Acne, Skin diseases, Acne therapy, Propionibacterium acnes, Acne vulgaris