ABSTRACTObjective: The current study aimed to investigate the effect of corn silk extracts (aqueous and methanolic) against obesity in an animal model.Methods: Animals were fed high-cholesterol diet (HCD) for 12 W to induce obesity and then treated either with Orlistat, corn silk extracts (aqueous andmethanolic) for 6 W. Anthropometric measurements (abdominal circumference [AC], thoracic circumference [TC], and body mass index [BMI]) wererecorded. Biochemical parameters including lipid profile (serum total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein, andlipase), glucose, insulin, and homeostasis model assessment of basal insulin resistance were assayed. Inflammatory cytokines visfatin, haptoglobin(Hp), afamin, endothelin-1, calprotectin, and protein S100B levels were quantified.Results: Significant decrease in TC, AC, and BMI was detected in HCD-fed groups treated with corn silk extracts with respect to HCD-fed group.Biochemical analyses indicated marked hypolipidemic and hypoglycemic effects of corn silk extracts. Treatment of HCD-fed groups with corn silkextracts experienced significant regression of visfatin, Hp, endothelin-1, calprotectin, and protein S100B levels relative to HCD-fed group.Conclusion: In conclusion, the current findings revealed the antiobesity potential of corn silk extracts. This effect may be attributed to its hypolipidemic,hypoglycemic, and anti-inflammatory properties of the active phytochemicals present in the extracts.Keywords: Obesity, Corn silk, Insulin resistance, Hyperlipidemia, Inflammation, Rodents
