Rheumatoid arthritis (RA) is an autoimmune and chronic inflammatory disease. Cytokine plays a significant role in modulating the immune systemand specifically the inflammation. The role of cytokines in disease has led to new development in the treatment of inflammatory diseases. Differentmediator cause inflammation, and degradation of joint cartilage in RA. Some of the novel target inhibitors, which are used to treat and control thisdisease are cyclooxygenase-2, tumor necrosis factor-α (TNF-α), TNF-α converting enzyme, interleukin-1, 6, 8, 10, 12, 15, 18, matrix metalloproteinase,nuclear factor κB, mitogen activated protein kinase, phosphodiesterase-4, janus kinase-signal transducer and activator of transcription, Bruton'styrosine kinase, spleen tyrosine kinase, Phosphatidylinositol-3-kinases. The mode of action and their progress in research have been covered in thisreview.Keywords: Disease-modifying anti-rheumatic drugs, Tumor necrosis factor-α converting enzyme, Tumor necrosis factor-α, Janus kinase, Spleentyrosine kinase, Phosphatidylinositol-3-kinases (PI3K)
