This paper aims to investigate the implications of Challenge Based Learning programs on entrepreneurial skills, mindset and intentions of university students using a quantitative approach. Using an original database, we analyzed pre and post levels of entrepreneurial skills, mindset and intention of 127 students who attended a Challenge Based Learning program. Results show a positive and significant effect of Challenge Based Learning programs on entrepreneurial mindset and skills – such as financial literacy, creativity and planning – of the students. Moreover, results show a positive but non-significative effect on entrepreneurial intention