The psychosocial factors on the development and progression of cancer have been a longstanding hypothesis since ancient times. In fact, epidemiological and clinical studies over past 30 years have provided strong evidence for links between chronic stress, depression, social isolation and cancer progression. By contrast, there is only limited intervention for managing behavioral factors in cancer progression. The major cause of death in cancer is metastasis that is resistant to conventional therapy. The outcome of cancer metastasis depends on multiple interactions between metastatic cells and homeostatic environment of the body. Epinephrine Norepinephrine Cortisol Catecholamine’s are known to be elevated in individuals with stress. The physiological stress response is thought to be one of the likely mediators in cancer progression, Hypothalamic Pituitary Adrenal (HPA) axis is considered to be the main neurophysiological mechanism of Shirodhara, the tactile stimulation of skin or hair follicles innervated by Trigeminal cranial nerve stimulate the thalamus and provide the subject an altered state of consciousness and a relief from anxiety, stress and depression. Other route from the principal nucleus to the reticular formation and posterior region of thalamus, which is Centre of autonomic nervous system, would be possible. This provides changes in autonomic nervous balance, Shirodhara can be treated as a good option to prevent stress and maintain homeostasis
