We aimed to investigate the relationship between single
nucleotide polymorphism (SNP) in the promoter region of the 5-HT-R2C
gene and stress-related disease psoriasis in the Turkish population. The
putative association between the 5-HTR2C variant (rs6318 Cys23Ser allele)
and patients with psoriasis was investigated. 100 patients with psoriasis
and 100 age-sex matched, unrelated healthy subjects representing
the control group were included in the study. The PCR-RFLP method
was used for genotyping the 5-HTR2C variation. There was no statistically
difference in terms of genotype distributions and allele frequencies
between the control subjects and patients with psoriasis (P=0.360
and P=0.439, respectively). The comparison between the presence and
absence of the 5-HTR2C gene rs6318 G allele within the determined
clinical subsets resulted in a significant difference with regard to treatment
methodology only when conventional therapy and one or more
medical therapy was compared (P=0.021). This study is the first clinical
study to investigate the association between 5-HTR2C polymorphism
and psoriasis. The role of the 5-HTR2C gene should be examined with
more parameters in a larger case series