The aim of this working paper is to contribute to the debate on how to identify regions with less developed research and innovation systems. We look at both conceptual and empirical approaches that figure prominently in scholarly work on regional innovation systems. Based on a critical review and discussion of the literature we shed light on a large number and variety of barriers and weaknesses that may hamper regional innovation and industrial change. It is shown in this paper that the regional innovation system concept can essentially inform the current debate on the design and implementation of smart specialisation strategies. It offers rich insights into various dimensions of regional innovation systems that may be weakly developed and allows for the development of typologies that capture the heterogeneity of these systems. We also demonstrate that empirical approaches to identify regions with less-developed research and innovation systems fall short of taking account of the conceptual advances made in the recent past
