PHENOTYPE FACILITIES OF LYMPHOCYTES IN HEMORRHAGIC FEVER WITH RENAL SYNDROME

Abstract

Hemorrhagic fever with renal syndrome (HFRS) is a feral herd disease caused by hantaviruses. HERS may be severe and its manifestations include acute renal failure, intoxication, hemorrhages and pain syndrome. Hantaviruses as pathogen of HFRS wield considerable influence on the character of the immune response, in particular, is capable of lymphocytic cytolysis suppressing. It was found that cytotoxic T lymphocytes along with NKT and CD8 + regulatory T cells play the key role in the immune mechanisms of hemorrhagic fever with renal syndrome. This reduces of the activation of lymphocytes with cytotoxic properties are closely related to the expression of NKG2D lectin receptors. Immunological signs of heavy currents HFRS can serve as a lack of growth on the part of natural killer and a significant drop in the number of b-lymphocytes in the blood, correlative related to the increase in CD8 + regulatory T cells