Pengaruh Praperlakuan Pemberian Jus Pisang Ambon Terhadap Profil Farmakokinetik Tetrasiklin Pada Tikus Putih Jantan

Abstract

Drugs could interact with food or other drugs. The use of tetracycline with milk or food containing calcium, magnesium or iron ions could reduce the absorption due to the formation of insoluble chelate. Banana contains ions such as calcium (10 mg), iron (0.9 mg), as well as water (72 g), protein (1.3 g), fat (0.2 g) and carbohydrates (26 g) in 100 g of edible parts. The aim of this research was to compare the pharmacokinetic profiles of tetracycline with pre-treatment of 1 hour, simultaneously and without administering ambon banana juice on white male rats. The method of this research was experimental, with “Posstest only control group design” and “one way anova” as the method of data analysis. The pharmacokinetic parameters of tetracycline were changed in group 1 by administering tetracycline 63 mg/kg BB, group 2 by administering of 2 mL of ambon banana juice 1 hour before tetracycline 63 mg/kg BB, and group 3 by administering of 2 mL of banana juice simultaneously with tetracycline 63 mg/kg BB. Pharmacokinetic parameter of tetracycline that changed were value of Ka, Cl, t1/2 el, Kel, tmaks, Cpmaks, and AUC. However, based on the results of one way analysis of variance on the value of tetracycline pharmacokinetic parameters between groups showed no significant difference (p>0.05). Key words: pharmakokinetics, ambon banana juice, tetracycline