Absract: Depression is a form of emotional disorder that show depressed feelings, sad, worthless, meaningless, don't have morale and pessimistic about the future felt by individuals. The purpose of this research is to know the relation of support families with depression in patients with chronic kidney disease. The research was carried out by the method of cross-sectional study, a sample of 59 respondents comprised of families and patients. Data collection is done by filling in a questionnaire made by researchers and is completed by respondents. Furthermore the data processed using the aid program SPSS for analysis by chi-square test with a level of significance of 0.05 (a).The research results showed that good family support (83.1%) with no depression (79,6%) whereas the depression (20.4%) and less support (16.9%) with depression (70,0%) and no depression (30,0%). Conclusion there is a meaningful relationship between family support with the depression, with a value of p = 0,004. Advice for health agencies in hospitals in order to further improve the quality of service to patients in order to prevent the risk of the occurrence of depression in patients with chronic kidney disease