90-95The mast
cell-mediated allergic reactions are involved in many allergic diseases, such
as asthma, allergic rhinitis and sinusitis. Stimulation of mast cells initiates
the process of degranulation, resulting in the release of mediators such as
histamine and an array of inflammatory cytokines. In this report, we
investigated the effect of gossypin (a biflavonoid) and suramin (a synthetic
polysulphonated naphtylurea) on the mast cell-mediated allergy model, and
studied the possible mechanism of their action. Both gossypin and suramin
inhibited (P<0.001) compound
48/80-induced systemic anaphylaxis reactions, antiprurities (P<0.001) and reduced the histamine
release in rats. Further, both showed significant (P<0.001) protection against rat peritoneal mast cells activated
by compound 48/80. Thus, our findings provide evidence that gossypin and
suramin inhibit mast cell-derived allergic reactions.</b